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Drugs not approved in Japan, oral medicines, and external medicines were excluded. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the “survival discharge.” Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. The survival rate of cardiac arrest patients is less than 10% therefore, development of a therapeutic strategy that improves their prognosis is necessary. 14Department of Biostatistics, Sapporo Medical University, Sapporo, Japan.13Department of Medical Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.12Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Urayasu, Japan.
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11Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.10Department of Medical Innovation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.9Department of Pharmacy, Nihon University Itabashi Hospital, Tokyo, Japan.
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8Department of Pharmacy, Kitakyushu City Yahata Hospital, Kitakyushu-shi, Japan.7Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Kita-ku, Japan.6Biomedical Informatics, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Kita-ku, Japan.5AWA Support Center, Tokushima University, Tokushima, Japan.4Department of Emergency Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.3Department of Clinical Evaluation and Development of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Kita-ku, Japan.2Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan.
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